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KMID : 1132720110090020059
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Genomics & Informatics
2011 Volume.9 No. 2 p.59 ~ p.63
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Lack of Replication of Genetic Association with Body Mass Index Detected by Genome-wide Association Study
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Lee Hae-In
Kim Jae-Jung
Park Tae-Sung
Kim Kyung-A
Lee Jong-Eun
Cho Yoon-Shin
Lee Jong-Young
Han Bok-Ghee
Lee Jong-Keuk
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Abstract
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Obesity provokes many serious human diseases, including various cardiovascular diseases and diabetes. Body mass index (BMI) is a highly heritable trait that is broadly used to diagnose obesity. To identify genetic loci associated with obesity in Asians, we conducted a genome-wide association study (GWAS) of a population of Korean adults (n=6,742, age 40~60 years) and detected six BMI risk loci (TNR, FAM124B, RGS12, NFE2L3, MC4R and FTO) having p<1x10(-5). However, in the replication study, only melanocortin 4 receptor gene (MC4R) (rs9946888, p=4.58x10(-7)) was replicated with marginal significance (p<0.05) in the second cohort (n=5,102, age 40~60 years). This study indicates that each locus associated with BMI has very weak genetic effect.
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KEYWORD
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genome-wide association study (GWAS), body mass index (BMI), Korean, single nucleotide polymorphism (SNP)
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